The problem, at least when running the HS as a VM, is that the HS connects to the wrong USB-device. I also read the posts that this should be possible to alter.
However, since I was starting the HS by ISO-file mount to the virtual CD-rom, I was not able to edit the file needed (no access to the linux system before the HS main starts.
A workaround is to make your own KNX IP-GW, by using a Raspbarry PI and the EIBD software. I got that to work, at least I managed to use the ETS to program the KNX-bus through that IP-gw. The HS can then talk to this IP-GW over multicast.